About 16 results found for searched term "Itk" (0.197 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M27849 | ITK antagonist | Itk |
| ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM. | ||
| M28149 | ITK inhibitor 2 | Itk |
| ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor, with an IC50 of 2 nM. | ||
| M43517 | ITK degrader 1 | Itk |
| ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice). | ||
| M43518 | ITK degrader 2 | Itk |
| ITK degrader 2 is a modulator of targeted ubiquitination and a targeted protein degrading molecule. | ||
| M2743 | GW2580 | CSF-1R (c-Fms) |
| SC-203877 | ||
| GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc. | ||
| M6519 | BMS 509744 | Others |
| BMS 509744 is a potent and selective ITK inhibitor. | ||
| M6636 | CTA 056 | BTK |
| CTA 056 is a iTK inhibitor. | ||
| M7120 | PF 06465469 | Others |
| PF 06465469 is a potent ITK inhibitor; also inhibits BTK. | ||
| M7536 | BMS-935177 | BTK |
| BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective. | ||
| M9889 | PCI-29732 | BTK |
| PCI29732 | ||
| PCI-29732 is a potent, reversible BTK inhibitor with Kiapp values of 8.2, 4.6, and 2.5 nM for BTK, Lck, and Lyn, respectively, and has only modest inhibitory activity against Itk, another Tec family kinase. In addition, PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP binding site of ABCG2. | ||
| M10896 | Vecabrutinib | BTK |
| SNS-062 | ||
| Vecabrutinib (SNS-062) is a potent, non-covalent BTK and ITK inhibitor,Kd The values are 0.3 nM and 2.2 nM, respectively. Vecabrutinib for ITK IC50 The value is 24 nM. | ||
| M11467 | GSK-2250665A | Itk |
| GSK2250665; GSK-2250665 | ||
| GSK-2250665A is a Itk inhibitor with pKi value of 9.2. | ||
| M14880 | BMX-IN-1 | BTK |
| BMX kinase inhibitor | ||
| BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity. | ||
| M28596 | GNE-9822 | Itk |
| GNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma. | ||
| M28620 | PRN694 | Itk |
| PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo. | ||
| M29440 | TL12-186 | PROTAC |
| TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM). | ||
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