About 8 results found for searched term "K-975" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7304 | SKF 97541 | Others |
| SKF 97541 is a extremely potent GABA B agonist. | ||
| M14198 | GSK-7975A | Calcium Channel |
| GSK-7975A is a potent and orally available CRAC channel inhibitor. | ||
| M21088 | K-975 | YAP |
| K-975 is a potent, selective and orally active TEAD inhibitor that strongly inhibits protein-protein interactions between YAP1/TAZ and TEAD. | ||
| M5073 | (R)-(+)-BAY K 8644 | Calcium Channel |
| (R)-(+)-Bay-K-8644; R-4407; NI-105; (+)-BAY-K-8644; Bayk8644 | ||
| (R)-(+)-BAY K 8644 is a calcium channel inhibitor, inhibits Ba2+ currents (IBa) with IC50 of 975 nM. | ||
| M11287 | JNJ-39758979 | Histamine Receptor |
| Jnj-39758979 is a selective, orally active, high-affinity histamine H4 receptor antagonist with Ki values of 12.5, 5.3 and 25 nM for human, mouse and monkey histamine H4 receptor, respectively. Jnj-39758979 antagonized histamine-induced cAMP inhibition with a pA2 of 7.9. Jnj-39758979 has good anti-inflammatory and antipruritic effects. | ||
| M20672 | INH14 | NF-κB |
| INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively. | ||
| M29837 | Akt3 degrader 1 | Akt |
| Akt3 degrader 1 (compound 12l) is a selective Akt3 degrader that overcomes Osimertinib-induced resistance in H1975OR NSCLC cells. Akt3 degrader 1 also has anti-proliferative activity and significantly inhibits tumour growth in mice. Akt3 degrader 1 can be used in the study of drug-resistant non-small cell lung cancer. | ||
| M55020 | AZD0780 | PCSK9 |
| Laroprovstat; PCSK9-IN-12; AZD-0780 | ||
| AZD0780 (PCSK9-IN-12, EX-A6975) is an oral, potentially first-in-class small molecule inhibitor of PCSK9. AZD0780 (PCSK9-IN-12, EX-A6975) has bind affinity for PCSK9 with a Kd value of ＜200 nM. AZD0780 (PCSK9-IN-12, EX-A6975) can be used for the research of cholesterol metabolism. | ||
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