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Jnj-39758979 is a selective, orally active, high-affinity histamine H4 receptor antagonist with Ki values of 12.5, 5.3 and 25 nM for human, mouse and monkey histamine H4 receptor, respectively. Jnj-39758979 antagonized histamine-induced cAMP inhibition with a pA2 of 7.9. Jnj-39758979 has good anti-inflammatory and antipruritic effects.
| Molecular Weight | 221.3 |
| Formula | C11H19N5 |
| CAS Number | 1046447-90-8 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
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