About 27 results found for searched term "IL-4-inhibitor-1" (0.135 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M55336 | IL-4-inhibitor-1 | IL Receptor/Related |
| IL 4 inhibitor 1 | ||
| IL-4-inhibitor-1 is the first IL-4 small-molecule inhibitor, with an EC50 of 1.81 µM. IL-4-inhibitor-1 features a nicotinonitrile scaffold with micromolar affinity and potency for the cytokine and disrupts type II IL-4 signaling in cells. | ||
| M2042 | Cilengitide | Integrin |
| EMD 121974, NSC 707544 | ||
| Cilengitide (EMD 121974, NSC 707544) is a selective inhibitor of αvβ3 integrin and αvβ5 integrin with IC50 of 1 nM and 140 nM, respectively. | ||
| M2346 | Filgotinib | JAK |
| GLPG0634 | ||
| Filgotinib (GLPG0634) is the first selective inhibitor of JAK1 and JAK2 with IC50 of 10nM and 28nM respectively. | ||
| M2980 | Rilpivirine (R278474) | Reverse Transcriptase |
| R278474, TMC278 | ||
| Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). | ||
| M3437 | Cilomilast | PDE |
| SB-207499 | ||
| Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. | ||
| M5246 | EW-7197 | TGF-β Receptor |
| Vactosertib; TEW-7197 | ||
| EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. | ||
| M5311 | AMG 925 | FLT3 |
| AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. | ||
| M8372 | Tienilic Acid | Others |
| Tienilic Acid (Ticrynafen) is a P450 inhibitor, a specific suicide substrate for CYP2C9 and CYP2C10. | ||
| M9026 | AZD-5153 HNT salt | Epigenetic Reader Domain |
| AZD5153 | ||
| AZD-5153 HNT salt is a potent, selective and orally available BET/BRD4 bromodomain inhibitor, disrupts BRD4 with an IC50 of 1.7 nM. | ||
| M10033 | Trilaciclib | CDK |
| G1T28; G1T-28 | ||
| Trilaciclib (G1T28) is a potent first-in-class reversible CDK4/6 inhibitor with IC50 of 1 nM and 4 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. | ||
| M11034 | Netarsudil (AR-13324) 2HCl | ROCK |
| AR-13324 | ||
| Netarsudil (AR-13324) is a Rho-kinase (ROCK) inhibitor with Ki values of 0.2-10.3 nM with potential intraocular pressure (IOP) lowering activity that inhibits both the ROCK and Rho pathways and increases atrial humor (AH) outflow and lowers IOP via the trabecular pathway, and may be used in glaucoma-related studies. | ||
| M11173 | PC945 | Others |
| PC945 is a potent antifungal triazole drug that is resistant to a variety of sensitive and resistant strains of Aspergillus fumigatus. PC945 is a potent, tightly bound inhibitor of aspergilloxine 14α-demethylase (CYP51A/CYP51B) activity.IC50s are 0.23 μM and 0.22 μM, respectively. | ||
| M14320 | Teneligliptin | Dipeptidyl Peptidase |
| MP-513 | ||
| Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM. | ||
| M14897 | AMG 925 HCl | FLT3 |
| AMG 925 HCl is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively. | ||
| M14910 | A-770041 | Src-bcr-Abl |
| A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. | ||
| M20652 | JNJ-38877618 | c-Met |
| JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable MET kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant MET (2 and 3 nM IC50). | ||
| M20882 | G1T38 | CDK |
| Lerociclib | ||
| Lerociclib (G1T38) is a novel, potent, selective, and orally bioavailable CDK4/6 inhibitor with IC50 values of 0.001 μM, 0.002 μM and 0.028 μM for CDK4, CDK6 and CDK9 respectively. | ||
| M21642 | Voxilaprevir (GS-9857) | HCV Protease |
| GS-9857 | ||
| Voxilaprevir (GS-9857) is a noncovalent, reversible inhibitor of HCV NS3/4A protease inhibitor (PI) with pangenotypic antiviral activity. Voxilaprevir inhibits genotype 1b and 3a wild-type NS3 proteases with Ki values of 0.038 nM and 0.066 nM, respectively. | ||
| M28201 | Quilseconazole | Antifungal |
| VT-1129 | ||
| Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes. | ||
| M28654 | Tilfrinib | Others |
| Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour. | ||
| M29155 | Tilpisertib | Serine/Threonine Protease |
| GS-4875 | ||
| Tilpisertib (GS-4875) is a serine/threonine kinase inhibitor (WO2017007689). | ||
| M30504 | Pentachloropseudilin | Myosin |
| Antibiotic A 15104 Y; PClP | ||
| Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β. | ||
| M30512 | Rilpivirine hydrochloride | Anti-infection |
| TMC-278 hydrochloride; TMC278 hydrochloride; TMC 278 hydrochloride | ||
| Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV. | ||
| M54866 | Recombinant Human USP14 (E.coli, N-6His) | Cytokines and Growth Factors |
| Ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14 | ||
| USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. | ||
| M55213 | Zanapezil | AChR/AChE |
| TAK-147; Zanapezil free base | ||
| Zanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor, it has potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). | ||
| M55216 | TH-Z145 | Antibiotic |
| THZ145 | ||
| TH-Z145 is a lipophilic GGPPS inhibitor (GGPPS IC50 = 210 nM). TH-Z145 is a very lipophilic bisphosphonate that lacks the cationic center essential for FPPS inhibition and is thus a specific GGPPS inhibitor (FPPS IC50 >30 mM). TH-Z145 exhibited strong prophylactic effects in a pathogenic influenza model. | ||
| M56592 | Enalaprilat | ACE |
| Enalaprilat (MK-422 anhydrous), the active metabolite of the oral proagent Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. | ||
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