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Tienilic Acid

Cat. No. M8372

All AbMole products are for research use only, cannot be used for human consumption.

Tienilic Acid Structure
Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 85  USD85 In stock
25mg USD 170  USD170 In stock
50mg USD 270  USD270 In stock
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Quality Control & Documentation
Biological Activity

Tienilic Acid (Ticrynafen) is a P450 inhibitor, a specific suicide substrate for CYP2C9 and CYP2C10. It was once used as a loop diuretic drug with uric acid-lowering (uricosuric) actvity, but was removed from market because of hepatotoxicity.

Chemical Information
Molecular Weight 331.17
Formula C13H8Cl2O4S
CAS Number 40180-04-9
Solubility (25°C) DMSO: 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Takayoshi Nishiya, et al. Involvement of cytochrome P450-mediated metabolism in tienilic acid hepatotoxicity in rats

[2] Takayoshi Nishiya, et al. The crucial protective role of glutathione against tienilic acid hepatotoxicity in rats

[3] M A Robin, et al. Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera

[4] J B Myers, et al. Effect of tienilic acid and amiloride in healthy volunteers and in hypertensives with normal renal function

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Keywords: Tienilic Acid supplier, inhibitors, activators

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