Free shipping on all orders over $ 500

Tienilic Acid

Cat. No. M8372

All AbMole products are for research use only, cannot be used for human consumption.

Tienilic Acid Structure
Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 85  USD85 In stock
25mg USD 170  USD170 In stock
50mg USD 270  USD270 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Tienilic Acid (Ticrynafen) is a P450 inhibitor, a specific suicide substrate for CYP2C9 and CYP2C10. It was once used as a loop diuretic drug with uric acid-lowering (uricosuric) actvity, but was removed from market because of hepatotoxicity.

Chemical Information
Molecular Weight 331.17
Formula C13H8Cl2O4S
CAS Number 40180-04-9
Solubility (25°C) DMSO: 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Takayoshi Nishiya, et al. Involvement of cytochrome P450-mediated metabolism in tienilic acid hepatotoxicity in rats

[2] Takayoshi Nishiya, et al. The crucial protective role of glutathione against tienilic acid hepatotoxicity in rats

[3] M A Robin, et al. Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera

[4] J B Myers, et al. Effect of tienilic acid and amiloride in healthy volunteers and in hypertensives with normal renal function

Related Products
PCL-PEG-MAL

PCL-PEG-MAL is an amphiphilic block copolymer consisting of polycaprolactone (PCL), polyethylene glycol (PEG) and maleimide (MAL) functional groups. PCL-PEG-MAL is used in targeted delivery systems, surface modification of nanomaterials, functionalisation of biomaterials and biosensing technologies for specific chemical linkages or biomolecular immobilisation.

DSPE-PEG-Streptavidin

DSPE-PEG-Streptavidin is an important biocoupling molecule widely used in biomedical research, especially in drug delivery, targeted therapies, immunodiagnostics and biosensors. Through the specific binding between streptavidin and biotin, DSPE-PEG-Streptavidin can help to achieve efficient loading and targeted action in targeted delivery systems. In addition, the molecule is widely used in molecular imaging and bioassays, especially for molecular recognition using the strong affinity between streptavidin and biotin in assay platforms that require high sensitivity and specificity.

E7107

E7107 is a first-in-class precursor messenger ribonucleic acid (pre-mRNA) spliceosome inhibitor.

KL044

KL044 is a stabilizer of the clock protein cryptochrome (CRY). KL044 is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity.

2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide

2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide is a biochemical material that can be used in scientific research.

  Catalog
Abmole Inhibitor Catalog




Keywords: Tienilic Acid supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.