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Teneligliptin hydrobromide hydrate

Cat. No. M5994
Teneligliptin hydrobromide hydrate Structure
Synonym:

MP-513 hydrobromide hydrate

Size Price Availability Quantity
10mg USD 58  USD58 In stock
50mg USD 172  USD172 In stock
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Quality Control & Documentation
Biological Activity

Teneligliptin (MP-513) hydrobromide hydrate is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor. Teneligliptin hydrobromide hydrate competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

Chemical Information
Molecular Weight 426.58
Formula C22H30N6OS
CAS Number 1572583-29-9
Solubility (25°C) DMSO ≥ 40 mg/mL
Water 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sharma SK, et al. Diabetes Metab Syndr Obes. Teneligliptin in management of type 2 diabetes mellitus.

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