About 8 results found for searched term "IC 261" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7846 | IC 261 | Casein Kinase |
| Casein kinase 1 δ (CK1δ) and CK1 ε inhibitor. | ||
| M14014 | S26131 | Melatonin Receptor |
| S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist. | ||
| M15015 | Recombinant Human Carbonic Anhydrase 1/CA1 (E.coli,C-6His) | Cytokines and Growth Factors |
| Carbonate Dehydratase I; Carbonic Anhydrase B | ||
| The recombinant human Carbonic Anhydrase 1/CA1 protein was produced by our escherichia coli expression system, and the target gene encoding ALA2-PHE261 was expressed at the C-terminal as 6His marker. Accession # : P00915. | ||
| M27782 | Veledimex | IL Receptor/Related |
| INXN-1001; RG-115932 | ||
| Veledimex (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system. Veledimex can be used to activate certain genes using the ecdysone receptor (EcR)-based inducible gene regulation system, the RheoSwitch Therapeutic System (RTS). Veledimex can cross blood-brain barrier (BBB) in both orthotopic GL-261 mice and cynomolgus monkeys. | ||
| M28057 | JTE-952 | CSF-1R (c-Fms) |
| JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. | ||
| M28428 | UCSF924 | Dopamine Receptor |
| UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole. | ||
| M29546 | CMLD012612 | Eukaryotic Initiation Factor |
| CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) and possesses potent anti-neoplastic activity. | ||
| M30894 | LP-261 | Microtubule |
| LP-261 is a potent and orally active anti-mitotic agent and shows an inhibition of in vitro tubulin polymerization with an EC50 of 3.2 μM. LP-261 inhibits growth of a human non-small-cell lung tumor (NCI-H522) in vivo and can be used for cancer research. | ||
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