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CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) and possesses potent anti-neoplastic activity.
| Molecular Weight | 559.61 |
| Formula | C31H33N3O7 |
| CAS Number | 2368900-35-8 |
| Form | Solid |
| Storage | Powder -20°C |
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