About 7 results found for searched term "GPX4-IN-4" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42431 | GPX4-IN-4 | Glutathione Peroxidase |
| GPX4-IN-4 is a potent GPX4 inhibitor. | ||
| M8380 | ML 210 | Others |
| Ml-210 is a selective, covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. Ml-210 binds GPX4 selenocysteine residues. ML210 has anticancer activity and has shown cytotoxic effects on melanoma, lung adenocarcinoma, fibrosarcoma and pancreatic cancer cell lines. | ||
| M10586 | JKE-1674 | Ferroptosis |
| JKE1674 | ||
| JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1. | ||
| M29297 | PKUMDL-LC-101-D04 | Glutathione Peroxidase |
| GPX4-Activator-1d4; PKU | ||
| PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts. | ||
| M42429 | GPX4-IN-5 | Glutathione Peroxidase |
| GPX4-IN-5 is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM. | ||
| M42430 | GPX4-IN-6 | Glutathione Peroxidase |
| GPX4-IN-6 is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. | ||
| M49462 | GPX4-IN-3 | Ferroptosis |
| GPX4-IN-3 is a potent glutathione peroxidase 4 (GPX4) inhibitor that selectively induces ferroptosis.1 μM of GPX4-IN-3 inhibited 71.7% of GPX4 activity. | ||
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