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Ml-210 is a selective, covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. Ml-210 binds GPX4 selenocysteine residues. ML210 has anticancer activity and has shown cytotoxic effects on melanoma, lung adenocarcinoma, fibrosarcoma and pancreatic cancer cell lines.
Mol Cell. 2024 Sep 14.
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer
ML 210 purchased from AbMole
| Molecular Weight | 475.32 |
| Formula | C22H20Cl2N4O4 |
| CAS Number | 1360705-96-9 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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