About 31 results found for searched term "Eg5-IN-1" (0.071 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41518 | Eg5-IN-1 | Kinesin |
| Eg5-IN-1 is a potent kinesin family motor protein (Eg5) inhibitor with an IC50 value of 1.97 µM. | ||
| M1669 | Regorafenib | VEGFR/PDGFR |
| BAY 73-4506 | ||
| Regorafenib (BAY 73-4506) is a novel oral multikinase inhibitor of c-KIT, VEGFR2, B-Raf with IC50s of 17, 40 and 69 nM respectively. | ||
| M1784 | Icotinib | EGFR/HER2 |
| BPI-2009H | ||
| Icotinib (BPI-2009H) is a potent and novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an IC50 of 5 nM. Iconitib inhibits the proliferation of A431 and BGC-823 A549, H460 and KB cell lines with IC50s of 1, 4.06, 12.16, 16.08, 40.71 μM. | ||
| M1964 | Vandetanib | VEGFR/PDGFR |
| ZD6474, Zactima | ||
| Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase (IC50=40 nM). Vandetanib also inhibited VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM). | ||
| M2042 | Cilengitide | Integrin |
| EMD 121974, NSC 707544 | ||
| Cilengitide (EMD 121974, NSC 707544) is a selective inhibitor of αvβ3 integrin and αvβ5 integrin with IC50 of 1 nM and 140 nM, respectively. | ||
| M2212 | Rociletinib (CO-1686) | EGFR/HER2 |
| AVL-301, CNX-419 | ||
| Rociletinib (CO-1686) is a potent, novel inhibitor of EGFR L858R/T790M kinase with Ki of 21.5 nM and 303.3 nM, respectively. | ||
| M2255 | Genistein | EGFR/HER2 |
| NPI 031L | ||
| Genistein is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. | ||
| M2595 | Raltegravir | Integrase |
| MK-0518 | ||
| Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectively. | ||
| M3026 | Sorafenib (BAY 43-9006) | Raf |
| BAY 43-9006 | ||
| Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Sorafenib is a multikinase inhibitor with IC50 values of 15 nM, 20 nM, 57 nM and 58 nM for VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib is a ferroptosis activator. | ||
| M3139 | ZM 306416 | VEGFR/PDGFR |
| CB 676475 | ||
| ZM 306416 is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM. | ||
| M3269 | KRN 633 | VEGFR/PDGFR |
| KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM, weakly inhibits PDGFR-α/β and c-Kit, does not block the phosphorylation of FGFR-1, EGFR or c-Met in cell. | ||
| M3484 | Dolutegravir | Integrase |
| GSK1349572 | ||
| Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. | ||
| M3684 | Canertinib dihydrochloride | EGFR/HER2 |
| CI-1033 dihydrochloride, Canertinib 2HCl, PD-183805 dihydrochloride | ||
| Canertinib 2HCl is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. | ||
| M4752 | L-Chicoric Acid | HIV Protease |
| (-)-Chicoric acid; trans-Caffeoyltartaric acid | ||
| L-chicoric Acid ((-)-Chicoric Acid), a dicafoyl tartaric Acid, is a potent, selective and reversible INHIBITOR of HIV-1 integrase with an IC50 of approximately 100 nM. L-chicoric Acid also inhibits HIV-1 replication in tissue cultures. | ||
| M4777 | Pregnenolone | Cannabinoid |
| Arthenolone; 3β-Hydroxy-5-pregnen-20-one | ||
| Pregnenolone (3β -hydroxy-5-pregnen-20-one) is a powerful neurosteroid, and is the major precursor of various steroids, including steroids. Pregnenolone is a specific signaling inhibitor of cannabinoid CB1 receptor. | ||
| M4805 | BIBX 1382 | EGFR/HER2 |
| Falnidamol | ||
| BIBX 1382 is a potent, selective inhibitor of EGFR tyrosine kinase (IC50 = 3 nM); displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). | ||
| M4894 | Cabozantinib malate | VEGFR/PDGFR |
| XL184;Cabozantinib S-malate | ||
| Cabozantinib malate (XL184) is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. | ||
| M5329 | Motesanib | c-Kit |
| AMG 706 | ||
| Motesanib (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret. | ||
| M5557 | Deferasirox | Cytochrome P450 (e.g. CYP17) |
| CGP-72670, ICL-670 | ||
| Deferasirox (ICL-670) is an iron chelator that causes iron loss that promotes BclxL downregulation and cell death. Deferasirox (ICL-670) also induced P450 3A4 and inhibited 2C8 and 1A2. | ||
| M5852 | Lifitegrast | Integrin |
| SAR 1118; Xiidra | ||
| Lifitegrast is an antagonist of integrin lymphocyte function associated antigen-1 (LFA-1). The IC50 of Jurkat T cells to icAM-1 was 2.98nM. Lifitegrast blocks the interaction between LFA-1 and ICAM-1, thereby reducing T cell activity and cytokine secretion. | ||
| M5925 | Regorafenib HCl | VEGFR/PDGFR |
| BAY73-4506 hydrochloride | ||
| Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. | ||
| M6508 | BIO5192 | Integrin |
| BIO-5192 | ||
| BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels. | ||
| M6650 | Daminozide | Histone demethylase |
| DaminoDaminozide is a plant growth regulator and selective inhibitor of human KDM2/7 histone demethylases, with IC50 values of 0.55, 1.5, and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively.Daminozide is >100-fold selective for KDM2/7 demethylases compared to other demethylase subfamily members tested. zide is a selective KDM2/7 inhibitor. | ||
| M7658 | BTA-1 | Others |
| BTA-1 is a probe for β-amyloid aggregates; fluorescent thioflavin-T derivative; exhibits high affinity for amyloid deposits; displays 50-fold higher affinity than thioflavin-T; selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice, as well as Aβ fibrils in postmortem brain tissue obtained from AD patients; crosses the blood brain barrier. | ||
| M8733 | K67 | Keap1-Nrf2 |
| K-67 | ||
| K67 is a specific inhibitor against the interaction between KEAP1 (Kelch-like ECH-associated protein 1) DC (double glycine repeat and C-terminal region) domain and S349-phosphorylated (human Ser349, mouse Ser351) KIR (Keap1-interacting region) of p62/SQSTM1, thereby preventing phospho-p62 from blocking KEAP1-DC and NRF2 (nuclear factor erythroid 2-related factor 2) DLGex motif association. | ||
| M11331 | UC2288 | Mdm2 |
| UC2288 is a novel p21 attenuator with cellular permeability and oral activity (relatively selective activity for P21), based on the structural synthesis of sorafenib. UC2288 down-regulated the expression of P21 mRNA and reduced the level of P21 protein independently of p53, and had little effect on the stability of P21 protein. UC2288 did not inhibit VEGFR2 and Raf kinases, even at 10 μM. | ||
| M8758 | GW806742X | Necroptosis |
| GW806742X is an ATP site-targeing kinase inhibitor (IC50 in nM = 2/VEGFR2, 15/SRC, 47/C-FMS, 851/GSK3, 9016/ERBB2, 9120/FGFR) with potent antiproliferation activity against cancer cultures (IC50 in nM = 5/HUVEC-v, 424/HUVEC-b, 81/HEF, 453/MDA468, 470/A375P, 693/HT29, 734/PC3), GW806742X is now better known as Compound 1 for its anti-necroptosis activity via affinity interaction with ML | ||
| M9094 | EG00229 Trifluoroacetate salt | VEGFR/PDGFR |
| EG-00229 Trifluoroacetate | ||
| EG00229 Trifluoroacetate is the first small molecule inhibitor of the neuropilin-1 and VEGF-A interaction with an IC50 of inhibition of 8 uM (125I-VEGF binding to PAE/NRP1 cells). | ||
| M9237 | dBET1 | Epigenetic Reader Domain |
| dBET1 is a potent BRD4 protein degrader with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 linked to NSC 527179 with a linker. | ||
| M9367 | Recombinant Human IL-15 Protein (HEK293, C-Fc) | Cytokines and Growth Factors |
| rH IL-15 | ||
| Recombinant Human IL-15 Protein is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 receptor (IL-15RA) with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. | ||
| M9540 | ODM-203 | VEGFR/PDGFR |
| ODM203 | ||
| ODM-203 is an orally available inhibitor of VEGFR and FGFR, with IC50s of 26, 9, 5 nM for VEGFR1, VEGFR2 and VEGFR3, and 11, 16, 6, 35 nM for recombinant FGFR1, FGFR2, FGFR3 and FGFR4, respectively. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
