Free shipping on all orders over $ 500

ZM 306416

Cat. No. M3139
ZM 306416 Structure
Synonym:

CB 676475

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 70  USD70 In stock
10mg USD 110  USD110 In stock
25mg USD 240  USD240 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

ZM 306416 is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM.

Customer Product Validations & Biological Datas
Source J Biomol Screen (2012). Figure 6. ZM 306416
Method Assessment of the anti-proliferative effects of hits against a panel of established cell lines
Cell Lines EGFR cell lines A549 and H2030
Concentrations 10 μM
Incubation Time -
Results Confirming the newly identified inhibitory activity of ZM-306416 toward EGFR, this compound induced selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011, while sparing the wild type EGFR cell lines A549 and H2030.
Chemical Information
Molecular Weight 333.74
Formula C16H13ClFN3O2
CAS Number 690206-97-4
Solubility (25°C) DMSO 47 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wei-Bin Wu, et al. Decreased PGF may contribute to trophoblast dysfunction in fetal growth restriction

[2] Christophe Antczak, et al. A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery

Related VEGFR/PDGFR Products
Oglufanide

Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus.

KLTWQELYQLKYKGI

KLTWQELYQLKYKGI (QK) is a VEGF mimicking peptide, binds to the VEGF receptors and competes with VEGF.

Protein LMWP

Protein LMWP is a cell-penetrating peptide with vascular endothelial growth factor (VEGF) inhibitory activity.

CBO-P11

CBO-P11 specifically binds to receptor of VEGFR-2 and is used as targeting ligand for tumor angiogenesis.

Aiphanol

Aiphanol is an extract of Poria cocos that directly targets and inhibits VEGFR2 and COX2, thereby blocking angiogenesis and tumor growth.

  Catalog
Abmole Inhibitor Catalog




Keywords: ZM 306416, CB 676475 supplier, VEGFR/PDGFR, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.