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Pregnenolone (3β -hydroxy-5-pregnen-20-one) is a powerful neurosteroid, and is the major precursor of various steroids, including steroids. Pregnenolone is a signal-transduction specific inhibitor of cannabinoid CB1 receptor, which inhibits the effects of THC mediated by CB1 receptor. Pregnenolone protects the brain against cannabis intoxication. Pregnenolone is also a TRPM3 pathway activator, and Pregnenolone can also induce weak activation of the TRPM1 pathway.
| Molecular Weight | 316.48 |
| Formula | C21H32O2 |
| CAS Number | 145-13-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Jui-Hsia Weng, et al. Nongenomic actions of neurosteroid pregnenolone and its metabolites
[2] Monique Valle. Neurosteroids and potential therapeutics: Focus on pregnenolone
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