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AM-2201

Cat. No. M2343
AM-2201 Structure
Size Price Availability Quantity
1mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

AM-2201 is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the CB1 and CB2 receptors, respectively. AM-2201 acts as a potent but nonselective full agonist for the cannabinoid receptor. The physiological actions and metabolism of AM2201 have not been characterized.

Customer Product Validations & Biological Datas
Source Drug Alcohol Depend (2017). Figure 2. AM2201
Method s.c.
Cell Lines Rats
Concentrations 0.1 – 0.3 mg/kg
Incubation Time 3 h
Results THC and XLR-11 were the least potent of the cannabinoids, while CP55,940 was the most potent. JWH-018 and AM2201 had comparable potency at increasing BP and were intermediate between CP55,940 and THC.
Chemical Information
Molecular Weight 359.44
Formula C24H22FNO
CAS Number 335161-24-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hutter M, et al. J Mass Spectrom. Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism.

[2] McQuade D, et al. Eur J Clin Pharmacol. First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201.

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