About 8 results found for searched term "DNMT-IN-3" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41211 | DNMT-IN-3 | Parasite |
| DNMT-IN-3 is an DNA Methyltransferase (DNMT) inhibitor, and plays an antimalarial role with IC50 of 60 nM against Plasmodium falciparum (Plasmodium). | ||
| M3008 | SGI-1027 | DNA Methyltransferase |
| DNA Methyltransferase Inhibitor II | ||
| SGI-1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B | ||
| M10985 | γ-Oryzanol | DNA Methyltransferase |
| γ-Oryzanol effectively inhibits DNA methyltransferases (DNMTs) in mouse striatum. Suppression of DNMT1 and DNMT3a,IC50 3.2 μM and 22.3 μM, respectively. | ||
| M13815 | GSK-3484862 | DNA Methyltransferase |
| GSK-3484862 is a non-covalent inhibitor for Dnmt1. GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates global demethylation in murine embryonic stem cells. | ||
| M41639 | DNMT-IN-1 | DNA Methyltransferase |
| DNMT-IN-1 is a potent DNMT inhibitor with an EC50 value of 3.2 µM. | ||
| M45092 | (R)-GSK-3685032 | DNA Methyltransferase |
| (R)-GSK-3685032 is the R-isomer of GSK-3685032.GSK-3685032 is a non-time-dependent, non-covalent, first-in-class, reversible selective inhibitor of DNMT1 with an IC50 value of 0.036 μM.GSK-3685032 induces DNA GSK-3685032 induces loss of DNA methylation, transcriptional activation and cancer cell growth inhibition. | ||
| M45093 | (S)-GSK-3685032 | DNA Methyltransferase |
| (S)-GSK-3685032 is the inactive isomer of GSK-3685032.GSK-3685032 is a non-time-dependent, non-covalent, first-in-class, reversible selective inhibitor of DNMT1 with an IC50 value of 0.036 μM.GSK-3685032 induces DNA GSK-3685032 induces loss of DNA methylation, transcriptional activation and cancer cell growth inhibition. | ||
| M58405 | Nanaomycin A | Parasite |
| Nanafrocin; Rosanomycina | ||
| Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM. | ||
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