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γ-Oryzanol

Cat. No. M10985
γ-Oryzanol Structure
Size Price Availability Quantity
500mg USD 48  USD48 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

γ-Oryzanol effectively inhibits DNA methyltransferases (DNMTs) in mouse striatum. Suppression of DNMT1 and DNMT3a,IC50 3.2 μM and 22.3 μM, respectively.

Chemical Information
Molecular Weight 602.89
Formula C40H58O4
CAS Number 11042-64-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mohamad Reza Toorani, et al. Food Chem. Effect of triacylglycerol structure on the antioxidant activity of γ-oryzanol

[2] Jisong Ahn, et al. Mol Nutr Food Res. γ-Oryzanol Improves Exercise Endurance and Muscle Strength by Upregulating PPARδ and ERRγ Activity in Aged Mice

[3] Ruru Liu, et al. Food Chem. Interactions between α-tocopherol and γ-oryzanol in oil-in-water emulsions

[4] Elham Ramazani, et al. Curr Pharm Des. Biological and Pharmacological Effects of Gamma-oryzanol: An Updated Review of the Molecular Mechanisms

[5] Wiramon Rungratanawanich, et al. Nutrients. γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice

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Keywords: γ-Oryzanol supplier, DNA Methyltransferase, inhibitors, activators


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