About 10 results found for searched term "CRM1" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M25250 | Transferrin aldifitox | Others |
| TF-CRM107 | ||
| Transferrin aldifitox (TF-CRM107) is a diphtheria toxin CRM107 conjugate with transferrin. Transferrin aldifitox can be used to research anticancer. | ||
| M42174 | CRM1-IN-1 | CRM1 |
| CRM1-IN-1 is a noncovalent CRM1 inhibitor. | ||
| M42175 | CRM1-IN-2 | CRM1 |
| CRM1-IN-2 is a noncovalent CRM1 inhibitor. | ||
| M5220 | Piperlongumine | Others |
| PPLGM, Piplartine | ||
| Piperlongumine, a natural alkaloid from Piper longum L., is also a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1. | ||
| M6903 | Leptomycin B | Antibiotic |
| CI 940; LMB | ||
| Leptomycin B (CI 940; LMB (LMB) is a protein exit nuclear transport inhibitor. Leptomycin deactivates CRM1/exportin 1 by covalent modification at cysteine residues. Leptomycin B is a potent antifungal antibiotic that blocks the eukaryotic cell cycle. | ||
| M9909 | Eltanexor | CRM1 |
| KPT-8602 | ||
| Eltanexor, also known as KPT-8602, is a second-generation exportin-1 (CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines. | ||
| M21722 | Felezonexor (CBS9106) | CRM1 |
| CBS9106; SL-801 | ||
| Felezonexor (CBS9106; SL-801) is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity without affecting CRM1 mRNA levels. Felezonexor is also a reversible inhibitor of XPO1, inhibits nuclear export by covalently binding to Cys528 as well as by inducing the degradation of XPO1. | ||
| M28308 | KPT-251 | CRM1 |
| KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity. | ||
| M29408 | AZ194 | Sodium Channel |
| AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects. | ||
| M30245 | PKF050-638 | HIV Protease |
| PKF050-638 is a potent and selective inhibitor of HIV-1 Rev (IC50=0.04 μM). PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction. | ||
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