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Piperlongumine is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1. Piperlongumine is also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells. Piperlonguminine inhibits alpha-melanocyte-stimulating hormone-induced melanogenesis by downregulation of tyrosinase expression in melanoma B16 cells. Piperlongumine also promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. Piperlongumine (50 mg/kg i.p.) causes in vivo growth inhibition of tumor cells.
| Molecular Weight | 317.34 |
| Formula | C17H19NO5 |
| CAS Number | 20069-09-4 |
| Solubility (25°C) | DMSO 16 mg/mL warmed |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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