About 19 results found for searched term "CK2 inhibitor 3" (0.135 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M45303 | CK2 inhibitor 3 | Casein Kinase |
| CK2 inhibitor 3 is a potent CK2 inhibitor with an IC50 of 280 nM that significantly affects tumor cell viability and exhibits significant selectivity for a panel of 320 kinases. | ||
| M2523 | CK-636 | Actin-Related Protein |
| CK-0944636 | ||
| CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. | ||
| M5156 | CCT241533 hydrochloride | Checkpoint |
| CCT241533 HCl | ||
| CCT241533 hydrochloride is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM. | ||
| M21033 | CK1-IN-1 | Casein Kinase |
| PUN51207, Compound 1C | ||
| CK1-IN-1 (PUN51207, Compound 1C) is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively. | ||
| M28240 | AZD4320 | Bcl-2 |
| AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively. | ||
| M28890 | WCK-4234 | Antibiotic |
| WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases. | ||
| M30022 | SRPIN803 | Casein Kinase |
| SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively. SRPIN803 exhibits antiangiogenic activity. SRPIN803 can be used for the research of age-related macular degeneration. | ||
| M30518 | ARP-100 | MMP |
| ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM). | ||
| M30749 | UCK2 Inhibitor-2 | Dehydrogenase |
| UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells. | ||
| M30853 | TMCB | Casein Kinase |
| TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct Ki values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively. | ||
| M30952 | Lck inhibitor 2 | Src-bcr-Abl |
| Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively IC50 Value: 13 nM(Lck) [1] Target: Src family kinase Lck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM). | ||
| M31200 | CK7 | CDK |
| CK-7 | ||
| CK7 is a Cdk2/9 inhibitor, which can be used for the synthesis of Nek1 inhibitor BSc5231 and BSc5367. | ||
| M41415 | CK1-IN-2 | Casein Kinase |
| CK1-IN-2 is a potent CK1 inhibitor with an IC50 values of 123, 19.8, 26.8, 74.3 nM for CK1a, CK1d, CK1e, p38a, respectively. | ||
| M41592 | THK01 | ROCK |
| THK01 is a potent ROCK2 inhibitor with IC50 values of 5.7 and 923 nM for ROCK2 and ROCK1, respectively. | ||
| M45289 | CK2 inhibitor 2 | Casein Kinase |
| CK2 inhibitor 2 is a potent, selective and orally active CK2 inhibitor with an IC50 value of 0.66 nM.CK2 inhibitor 2 shows high selectivity for Clk2 (IC50=32.69 nM)/CK2 and possesses good anti-proliferative and anti-tumor activity. | ||
| M45293 | BRD4/CK2-IN-1 | Casein Kinase |
| BRD4/CK2-IN-1 is a potent, orally active dual-targeted inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2) with IC50 values of 180 nM and 230 nM, respectively.BRD4/CK2-IN-1 exhibits potent anticancer activity without significant toxicity and induces apoptosis and autophagy-related cell death in triple-negative breast cancer (TNBC). autophagy-related cell death in triple negative breast cancer (TNBC). | ||
| M45300 | CK2/PIM1-IN-1 | Casein Kinase |
| CK2/PIM1-IN-1 is an inhibitor of CK2 and PIM1 with IC50 values of 3.787 μM and 4.327 μM for the effects of CK2 and PIM1, respectively.CAS 번호410483-84-5 | ||
| M45305 | CK2-IN-9 | Casein Kinase |
| CK2-IN-9 is a potent selective inhibitor of CK2 kinase with an IC50 of 3 nM, and also reduces the reporter activity of Wnt with an IC50 of 75 nM. In addition, CK2-IN-9 is characterized by low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) in rats. | ||
| M49772 | Akt/ROCK-IN-1 | ROCK |
| Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively. | ||
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