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WCK-4234 

Cat. No. M28890

All AbMole products are for research use only, cannot be used for human consumption.

WCK-4234  Structure

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Quality Control & Documentation
Biological Activity

WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases.

Chemical Information
Molecular Weight 269.21
Formula C7H8N3NaO5S
CAS Number 1804915-68-1
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage -20°C, dry, sealed
References

[1] Kiran Patil, et al. Biomed Chromatogr. Simultaneous determination of novel β-lactamase inhibitor WCK 4234 and Meropenem in dog plasma by LC-MS/MS and its application to preclinical pharmacokinetic study

[2] Alejandro Iregui, et al. Antimicrob Agents Chemother. Activity of Meropenem with a Novel Broader-Spectrum β-Lactamase Inhibitor, WCK 4234, against Gram-Negative Pathogens Endemic to New York City

[3] Krisztina M Papp-Wallace, et al. J Med Chem. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234

[4] Shazad Mushtaq, et al. J Antimicrob Chemother. WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases

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  Catalog
Abmole Inhibitor Catalog




Keywords: WCK-4234  supplier, Antibiotic, inhibitors, activators

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