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BRD4/CK2-IN-1 is a potent, orally active dual-targeted inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2) with IC50 values of 180 nM and 230 nM, respectively.BRD4/CK2-IN-1 exhibits potent anticancer activity without significant toxicity and induces apoptosis and autophagy-related cell death in triple-negative breast cancer (TNBC). autophagy-related cell death in triple negative breast cancer (TNBC).
| Molecular Weight | 564.03 |
| Formula | C29H30ClN5O5 |
| CAS Number | 2756851-99-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Shwu-Yuan Wu, et al. Mol Cell. Opposing Functions of BRD4 Isoforms in Breast Cancer
[5] Benedetta Donati, et al. Mol Cancer. BRD4 and Cancer: going beyond transcriptional regulation
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