Certificate of Analysis
| Product Name: | BRD4/CK2-IN-1 |
| Catalog Number: | M45293 |
| CAS Number: | 2756851-99-5 |
Physical and Chemical Properties
| Formula: | C29H30ClN5O5 |
| Molecular Weight: | 564.03 |
| Form: | Solid |
| Solubility: | DMSO 20 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | BRD4/CK2-IN-1 is a potent, orally active dual-targeted inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2) with IC50 values of 180 nM and 230 nM, respectively.BRD4/CK2-IN-1 exhibits potent anticancer activity without significant toxicity and induces apoptosis and autophagy-related cell death in triple-negative breast cancer (TNBC). autophagy-related cell death in triple negative breast cancer (TNBC). |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |