About 11 results found for searched term "BET-IN-14" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41658 | BET-IN-14 | Epigenetic Reader Domain |
| BET-IN-14 is an orally active pan BET inhibitor (IC50: 5.35 nM). | ||
| M3001 | SC144 | IL Receptor/Related |
| SC144 is the first oral active GP130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, eliminates Stat3 phosphorylation and nuclear translocation, and further inhibits downstream target gene expression. SC144 inhibited signal transduction induced by GP130 ligand. SC144 induces apoptosis of human ovarian cancer cells. | ||
| M6102 | Pembrolizumab | PD-1/PD-L1 |
| Lambrolizumab; MK-3475 | ||
| Pembrolizumab (pembrolizumab) is a humanized anti-PD-1 monoclonal antibody that blocks the interaction between PD-1 and its ligands PD-L1 and PD-L2. It has immune checkpoint inhibitory activity and antitumor activity. MW: 146.286 KD.(Pembrolizumab does not recognize murine PD-1 protein, humanized mice or mice expressing human PD-1 gene are required). | ||
| M7273 | SC 144 hydrochloride | IL Receptor/Related |
| SC144 hydrochloride is the first oral active GP130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, inducing phosphorylation (S782) and deglycosylation of GP130, eliminating Stat3 phosphorylation and nuclear translocation, and further inhibiting the expression of downstream target genes. SC144 hydrochloride inhibited signal transduction induced by GP130 ligand. SC144 hydrochloride induces apoptosis of human ovarian cancer cells. | ||
| M8868 | Zerumbone | Anti-infection |
| Zerumbone is a TRAIL-induced apoptosis potentiator. Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. | ||
| M10759 | GSK046 | Epigenetic Reader Domain |
| iBET-BD2 | ||
| GSK046 (iBET-BD2) is an effective, selective and orally active inhibitor of the BD2 bromine domain of the BET protein,IC50 The values are 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2), and 214 nM (BRDT BD2). GSK046 has immunomodulatory activity. | ||
| M10828 | GSK778 | Epigenetic Reader Domain |
| iBET-BD1 | ||
| GSK778 (iBET-BD1) is a potent and selective inhibitor of the BD1 bromine domain of the BET protein,IC50 The values are 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1). GSK778 phenotyping the role of pan-BET inhibitors in cancer models. | ||
| M29032 | FK614 | PPAR |
| FK614 is an orally active, non-thiazolidinedione (TZD) type, and selective PPARγ modulator (SPPARM). FK614 functions as a PPARγ agonist with potent anti-diabetic activity in vivo. FK614 has different effects on the activation of PPARγ at each stage of adipocyte differentiation. FK614 can be used for the research of hyperglycemia, hypertriglyceridemia, glucose intolerance and type 2 diabetes. | ||
| M29783 | DS20362725 | Estrogen Receptor |
| DS20362725 is an estrogen-related receptor α (ERRα) agonist. DS20362725 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC50 value of 0.6 μM. DS20362725 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM). | ||
| M29784 | DS45500853 | Estrogen Receptor |
| DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC50 value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM). | ||
| M55236 | Recombinant Mouse LTBR Protein (HEK293, C-Fc) | Cytokines and Growth Factors |
| Lymphotoxin-beta receptor | ||
| Lymphotoxin Beta Receptor is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. | ||
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