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DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC50 value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM).
| Molecular Weight | 284.35 |
| Formula | C18H20O3 |
| CAS Number | 2735803-28-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Tsuyoshi Shinozuka, et al. ACS Med Chem Lett. Discovery of a Novel Class of ERRα Agonists
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