About 30 results found for searched term "AZ-3" (0.009 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1657 | Atazanavir Sulfate | HIV Protease |
| BMS-232632, Reyataz, CGP-73547 | ||
| Atazanavir sulfate (BMS-232632, Reyataz) is an azapeptide inhibitor of HIV-1 protease. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. | ||
| M1659 | Saracatinib | Src-bcr-Abl |
| AZD0530 | ||
| Saracatinib (AZD0530) is an orally active small molecule Src inhibitor. | ||
| M1662 | AZD8330 | MEK |
| ARRY-424704, ARRY-704 | ||
| AZD8330 (ARRY-424704) is a novel, selective, highly efficacious, uncompetitive MEK inhibitor with an IC50 of 7 nM. | ||
| M1667 | Sapitinib (AZD8931) | EGFR/HER2 |
| AZD-8931 | ||
| AZD8931 (Sapitinib) is an equipotent, reversible inhibitor of Signaling by EGFR, ERBB2 (HER2), and ERBB3 with IC50 of 4, 3, 4 nM respectively. | ||
| M1696 | Cediranib | VEGFR/PDGFR |
| AZD2171; NSC-732208 | ||
| Cediranib (AZD2171) inhibited VEGFR2 and KDR phosphorylation with IC50s of 0.4 and 0.5 nM, respectively. | ||
| M1738 | Niltubacin | HDAC |
| MAZ-1391 | ||
| Niltubacin, as an inactive derivative of Tubacin, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6. | ||
| M1810 | AZD5438 | CDK |
| AZD 5438 | ||
| AZD5438 is a novel, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). | ||
| M2092 | AZD3514 | Androgen Receptor |
| AZD3514 is a potent, orally activie and selective androgen receptor (AR) inhibitor with potential anticancer cancer activity. | ||
| M2109 | AZD3463 | ALK |
| ALK/IGF1R inhibitor | ||
| AZD3463 is a novel ALK/IGF1R inhibitor with IC50 value of 22 nM. | ||
| M2128 | AZ3146 | Kinesin |
| AZ 3146 | ||
| AZ3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor with IC50 of 35 nM. | ||
| M2303 | Capivasertib (AZD5363) | Akt |
| AZD-5363 | ||
| Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2. | ||
| M2421 | AZD3839 | BACE |
| AZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM. | ||
| M2422 | AZD5423 | GCR |
| AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist. | ||
| M3194 | Nocodazole | Src-bcr-Abl |
| Oncodazole；R17934 | ||
| Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. | ||
| M3876 | 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile | Others |
| 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile | ||
| M1587 | Hydroxy Itraconazole | Antibiotic |
| Hydroxy Itraconazole; R-63373 | ||
| Itraconazole metabolite Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent. | ||
| M4424 | Tetramethylpyrazine (2,3,5,6-Tetramethylpyrazine) | Apoptosis |
| Chuanxiongzine; Tetramethylpyrazine；Ligustrazine | ||
| Tetramethylpyrazine (2,3,5,6-Tetramethylpyrazine) is an alkyl pyrazine extracted from Ligusticum wallichii (Chuan Xiong), often used as a flavor in French fries, bread, tea, dairy products, bean products and other food. Ligustrazine has potential antineural and anti-inflammatory activities in rats. | ||
| M4854 | BMN-673 8R,9S | PARP |
| Talazoparib (8R,9S); (8R,9S)-LT-673 | ||
| BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673.BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2. | ||
| M5164 | AZD3759 | EGFR/HER2 |
| Zorifertinib | ||
| AZD3759 (Zorifertinib) is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. | ||
| M5189 | AZD3965 | Monocarboxylate Transporter (MCT) |
| AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM. | ||
| M5227 | AZD3293 | BACE |
| LY3314814 | ||
| AZD3293, also known as LY3314814 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. | ||
| M5313 | AZD2932 | VEGFR/PDGFR |
| AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively. | ||
| M5314 | AZD-8835 | PI3K |
| AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM). | ||
| M5479 | Carsalam | Others |
| Carbonylsalicylamide; 2H-1,3-Benzoxazine-2,4(3H)-dione | ||
| Carsalam (Carbonylsalicylamide) is a non-steroidal anti-inflammatory compound. | ||
| M5863 | Pazopanib HCl (GW786034) | VEGFR/PDGFR |
| GW786034; Pazopanib Hydrochloride | ||
| Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. | ||
| M6180 | AZD3264 | IκB/IKK |
| AZD3264 is a novel IKK2 inhibitor. | ||
| M6294 | AZD-7594 | GCR |
| AZ13189620; Velsecorat | ||
| AZD7594 is an inhaled, nonsteroidal, potent, and selective modulator of the glucocorticoid receptor (GR). | ||
| M6478 | AZ Dyrk1B 33 | Others |
| AZ Dyrk1B 33 is a potent and selective Dyrk1B kinase inhibitor. | ||
| M6479 | AZ PFKFB3 26 | PFKFB3 |
| AZ PFKFB3 26 is a potent and selective PFKFB3 inhibitor. | ||
| M6480 | AZD 1283 | P2 Receptor |
| AZD 1283 is a high affinity P2Y 12 antagonist. | ||
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