About 25 results found for searched term "AB10" (0.053 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1838 | Masitinib | VEGFR/PDGFR |
| AB1010 | ||
| Masitinib is a tyrosine kinase inhibitor targeting stem cell factor receptor (c-kit) and platelet-derived growth factor (PDGF) receptor. | ||
| M3813 | Avelumab (MSB0010718C) | PD-1/PD-L1 |
| MSB0010718C | ||
| Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). Avelumab recognizes murine PD-L1 | ||
| M1615 | Obinutuzumab | CD20 |
| afutuzumab; GA101 | ||
| Obinutuzumab (GA101) is a fully humanized monoclonal antibody that binds to an epitope on CD20. | ||
| M9640 | MMP-9-IN-1 | MMP |
| ABM-7710 | ||
| MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor. | ||
| M10337 | Avitinib (AC0010) | EGFR/HER2 |
| Abivertinib; AC-0010 | ||
| Avitinib (Abivertinib; AC0010) is a third-generation irreversible EGFR tyrosine kinase inhibitor, with potential antineoplastic activity. | ||
| M10665 | Masitinib mesylate | c-Kit |
| AB-1010 mesylate | ||
| Masitinib (AB-1010) mesylate is a potent, orally bioavailable and selective inhibitor of c-Kit, IC50 of 200 nM for human recombinant c-Kit. It also inhibits PDGFRα/β, LynB with IC50 values of 540, 800 and 510 nM. | ||
| M10936 | Taletrectinib | Trk |
| DS-6051b; AB-106; IBI-344 | ||
| Taletrectinib (DS-6051b) is a potent orally active next-generation selective ROS1/NTRK inhibitor. Taletrectinib is 0.207, 0.622, 2.28, and 0.98 nM, respectively IC50 It has a strong inhibitory effect on recombinant ROS1, NTRK1, NTRK2 and NTRK3. Taletrectinib also inhibits ROS1 G2032R and other ANTI-Crizotinib ROS1 mutants. | ||
| M16520 | 2α,7β,13α-Triacetoxy-5α-cinnamoyloxy-9β- hydroxy-2(3→20)abeotaxa-4(20),11-dien-10-one | Diterpenoids |
| 2α,7β,13α-Triacetoxy-5α-cinnamoyloxy-9β- hydroxy-2(3→20)abeotaxa-4(20),11-dien-10-one | ||
| M17476 | 1-Hydroxybisabola-2,10-dien-4-one | Sesquiterpenoids |
| 1-Hydroxybisabola-2,10-dien-4-one | ||
| M17497 | Bisabola-3,10-dien-2-one | Sesquiterpenoids |
| Bisabola-3,10-dien-2-one | ||
| M24549 | Crenezumab | Amyloid |
| MABT 5102A; RG 7412 | ||
| Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, for use in Alzheimer's disease research. | ||
| M25073 | Socazolimab | PD-1/PD-L1 |
| ZKAB001; STI-1014; STI-A1014 | ||
| Socazolimab (ZKAB001) is an anti-PD-L1 monoclonal antibody. Socazolimab has lasting safety and efficacy in the treatment of recurrent or metastatic cervical cancer. Socazolimab also has potential applications in small cell lung cancer, esophageal squamous cell carcinoma (ESCC), advanced urothelial carcinoma and osteosarcoma. | ||
| M25270 | Conatumumab | TNF Receptor |
| AMG 655; TRAIL-R2 mAb Human Anti-TNFRSF10B Recombinant Antibody | ||
| Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. . | ||
| M28767 | Elsubrutinib | BTK |
| ABBV-105 | ||
| Elsubrutinib (ABBV-105) is an orally active, potent, selective and irreversible Bruton's tyrosine kinase (BTK) inhibitor。The IC50 of Elsubrutinib for BTK catalytic domain is 0.18 μM. Elsubrutinib can be used for the research of inflammatory disease. | ||
| M30111 | ABT-100 | Farnesyl Transferase |
| ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. | ||
| M38771 | 1,4-Epidioxybisabola-2,10-dien-9-one | Anti-infection |
| 1,4-Epidioxybisabola-2,10-dien-9-one is a 1,4-epidioxy-bisabola-2,12-diene derivate, which can be isolated from Curcuma longa L. 1,4-Epidioxybisabola-2,10-dien-9-one exhibits antiviral activity against influenza virus A/PR/8/34 (H1N1) in the MDCK cell line with an IC50 of 16.79 ± 4.03 μg/mL. | ||
| M40695 | ABBV-101 | PROTAC |
| ABBV-101 is a degradation agent that targets BTK and can be used in studies related to non-Hodgkin's lymphoma. | ||
| M41002 | AcLys-PABC-VC-Aur0101 intermediate-1 | ADC Linker |
| AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. | ||
| M42707 | AB10 | Sigma Receptor |
| AB10 is a selective S1R antagonist. | ||
| M53417 | ABT-510 | Apoptosis |
| ABT-510 is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. | ||
| M54140 | ABT-510 acetate | Apoptosis |
| ABT-510 acetate is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. | ||
| M56539 | ABT-107 | AChR/AChE |
| ABT-107 is a selective α7 neuronal nicotinic receptor agonist. | ||
| M57768 | Cabergoline Impurity 10 | Others |
| Cabergoline Impurity 10 | ||
| M58324 | ABT-102 | TRP Channel |
| ABT102; CHEMBL398338 | ||
| ABT-102 (CHEMBL398338) is a potent and highly selective transient receptor potential vanilloid 1 (TRPV1) receptor antagonist. | ||
| M58326 | (S)-ABT-102 | TRP Channel |
| (S)-ABT-102 is a potent TRPV1 antagonist, with an IC50 of 123 nM. (S)-ABT-102 can block the activation of TRPV1 by capsaicin. | ||
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