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MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor. MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9, with Kd value of 2.1 μM. MMP-9-IN-1 (10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells. In vivo, MMP-9-IN-1 (20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.
| Molecular Weight | 369.39 |
| Formula | C16H17F2N3O3S |
| CAS Number | 502887-71-0 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MMP Products |
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| KP-457
KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with IC50 of 11.1 nM (cell-free assay). KP-457 also cleaves various molecules such as GPIbα, GPV, and TNF-α. |
| MMP2-IN-1
MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis. |
| MMP-9 Inhibitor I
MMP-9 inhibitor I is a cell-permeable, potent, selective, and reversible inhibitor of MMP-9 (IC50 = 5 nM). MMP-9 inhibitor I also inhibits MMP-1 (IC50 = 1.05 µM) and MMP-13 IC50 = 113 nM) at higher concentrations. |
| BPHA
BPHA is a potent and orally active MMP-2, MMP-9 and MMP-14 inhibitor with IC50s of 12 nM, 16 nM and 17 nM, respectively. |
| ONO-4817
ONO-4817 is a potent inhibitor of matrix metalloproteinase (MMP). |
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Products are for research use only. Not for human use. We do not sell to patients.
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