All AbMole products are for research use only, cannot be used for human consumption.
MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor. MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9, with Kd value of 2.1 μM. MMP-9-IN-1 (10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells. In vivo, MMP-9-IN-1 (20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.
| Molecular Weight | 369.39 |
| Formula | C16H17F2N3O3S |
| CAS Number | 502887-71-0 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MMP Products |
|---|
| MMP2-IN-1
MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis. |
| MMP-9 Inhibitor I
MMP-9 inhibitor I is a cell-permeable, potent, selective, and reversible inhibitor of MMP-9 (IC50 = 5 nM). MMP-9 inhibitor I also inhibits MMP-1 (IC50 = 1.05 µM) and MMP-13 IC50 = 113 nM) at higher concentrations. |
| BPHA
BPHA is a potent and orally active MMP-2, MMP-9 and MMP-14 inhibitor with IC50s of 12 nM, 16 nM and 17 nM, respectively. |
| ONO-4817
ONO-4817 is a potent inhibitor of matrix metalloproteinase (MMP). |
| UK-370106
UK-370106 is a potent and highly selective MMP-3 (IC50 of 23 nM) and MMP-12 (IC50 of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
