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NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.
| Molecular Weight | 260.16 |
| Formula | C12H15Cl2NO |
| CAS Number | 7497-07-6 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MMP Products |
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| MMP2-IN-1
MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis. |
| MMP-9 Inhibitor I
MMP-9 inhibitor I is a cell-permeable, potent, selective, and reversible inhibitor of MMP-9 (IC50 = 5 nM). MMP-9 inhibitor I also inhibits MMP-1 (IC50 = 1.05 µM) and MMP-13 IC50 = 113 nM) at higher concentrations. |
| BPHA
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| ONO-4817
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| UK-370106
UK-370106 is a potent and highly selective MMP-3 (IC50 of 23 nM) and MMP-12 (IC50 of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. |
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