All AbMole products are for research use only, cannot be used for human consumption.
Dipeptidyl peptidase-4 (DPP4) is a serine exopeptidase belonging to the S9B protein family. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP).
The recombinant human DPP-4 expressed the sequence encoding the extracellular domain (Asn 29-Pro 766) of the mature form of human DPPIV with the fused Fc region of human IgG1 at the N-terminus.
Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin, the specific activity is > 2000 pmoles/min/μg.
Accession: P27487
Apparent Molecular Weight: 120-130 kDa, under reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from sterile 25 mM MES, 150 mM NaCl, pH 6.5.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Related Enzymes & Regulators Products |
|---|
| Recombinant Human SOD1 Protein (E. coli, N-6His)
SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. SOD1 neutralizes supercharged oxygen molecules, which can damage cells if their levels are not controlled. The enzyme protects the cell against dangerous levels of superoxide. |
| Recombinant Human SOD2 (HEK293, C-6His)
SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. |
| Recombinant Human MMP13 Protein (E. coli, N-His)
The MMP-13 protein plays a role in the degradation of extracellular matrix proteins, especially fibrillar collagen, fibronectin, TNC, and ACAN. It cleaves triple-helical collagen, preferentially cleaves type II collagen, and can also target other collagen types. |
| Recombinant Mouse DPP-4/CD26 Protein (HEK293, N-hFc)
Dipeptidyl peptidase-4 (DPP4, CD26) is a serine exopeptidase belonging to the S9B protein family. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). |
| Recombinant Human DPP4/CD26 (HEK293, C-6His)
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
