About 22 results found for searched term "4-IPP" (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2359 | 4-Aminohippuric Acid | Metabolite/Endogenous Metabolite |
| p-Aminohippuric acid | ||
| 4-Aminohippuric acid is a typical substrate of organic anion transport systems. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow. | ||
| M6345 | 4-IPP | Macrophage Migration Inhibitory Factor |
| 4-Iodo-6-phenylpyrimidine | ||
| 4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF) and specific suicide substrate. | ||
| M41391 | 4-Fluorohippuric acid | Others |
| 4-Fluorohippuric acid is a major metabolite of flupirtine with research potential against pain and epilepsy. | ||
| M10963 | ARCC-4 | Others |
| ARCC-4 is based on PROTAC technology, a nanomolar grade androgen receptor (AR) degrader D50 The value is 5 nM. ARCC-4 is an AR PROTAC recruited by von Hippel-Lindau (VHL) based on enzalutamide. ARCC-4 effectively degrades AR mutations associated with antiandrogen studies. | ||
| M14870 | dTRIM24 | PROTAC |
| dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24. | ||
| M21032 | GMB-475 | PROTAC |
| GMB-475 is a proteolysis-targeting chimera (PROTAC) that allosterically targets BCR-ABL1 protein and recruit the E3 ligase Von Hippel-Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein. | ||
| M21455 | Casimersen | Others |
| Casimersen (SRP-4045) is an antisense oligonucleotide of the subclass of phosphodiamide morphorph oligomers. Casimersen binds to exon 45 of dystrophin's precursor mRNA to restore the open reading frame (by skipping exon 45), resulting in an internally truncated but functional dystrophin. Casimersen can be used in the study of Duchenne muscular dystrophy (DMD). | ||
| M27803 | Leucettine L41 | CDK |
| Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 µM, respectively). Leucettine L41 prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by Aβ25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity. Leucettine L41 also prevents memory deficits induced by Aβ25-35 in the same model. | ||
| M28534 | NE-100 hydrochloride | Sigma Receptor |
| NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death. | ||
| M29104 | MZP-54 | PROTAC |
| MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 4 nM for Brd4BD2. | ||
| M29120 | JNJ-61432059 | GluR |
| JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models. | ||
| M29228 | BRD4 degrader AT1 | PROTAC |
| BRD4 degrader AT1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 as a highly selective Brd4 degrader, with a Kd of 44 nM for Brd4BD2 in cells. | ||
| M29501 | PROTAC BRD4 Degrader-3 | PROTAC |
| PROTAC BRD4 Degrader-3 (compound 1004.1) is an efficacious PROTAC connected by ligands for von Hippel-Lindau and BRD4. | ||
| M29559 | SIAIS178 | PROTAC |
| SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity. | ||
| M29762 | MS432 | PROTAC |
| MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively. | ||
| M30397 | VU10010 | AChR/AChE |
| VU10010 is a potent, highly selective and allosteric M4 mAChR potentiator with an EC50 of 400 nM. VU10010 binds to an allosteric site on M4 mAChR and increases affinity for acetylcholine and coupling to G proteins. VU10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus. | ||
| M39698 | 2'',4''-Di-O-(Z-p-Coumaroyl)afzelin | Others |
| 2'',4''-Di-O-(Z-p-Coumaroyl)afzelin (compound 9) is a compound isolated from the leaf extract of Machilusphilippinense Merr.. | ||
| M42910 | PDCD4-IN-1 | Others |
| PDCD4-IN-1is a PDCD4 inhibitor with a Kd value of 350 nM, which can promote the expression of BDNF in hippocampal neuron cell HT-22. | ||
| M43414 | JPS014 TFA | HDAC |
| JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). | ||
| M49788 | 4′-Demethylnobiletin | PKA |
| 4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signal | ||
| M54683 | PROTAC IRAK4 degrader-3 | IRAK |
| PROTAC IRAK4 degrader-3 is a von Hippel-Lindau based IRAK4 degrader PROTAC. | ||
| M57167 | XY028-133 | PROTAC |
| XY028-133 is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK. | ||
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