About 5 results found for searched term "126-18-1" (0.202 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3801 | TCS 21311 | JAK |
| TCS 21311 is a potent JAK3 inhibitor with IC50 of 8 nM. | ||
| M10864 | Nicodicosapent | Others |
| Nicodicosapent is a fatty acid niacin conjugate that inhibits the activity of sterol regulatory element binding proteins (SREBP) and the activity of proteins that regulate cholesterol metabolism such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1. | ||
| M14006 | Smilagenin | AChR/AChE |
| Smilagenin (SMI) is a small-molecule steroidal sapogenin from Rhizoma anemarrhenae and Radix asparagi widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. | ||
| M28794 | JZP-MA-11 | MAGL |
| JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP). | ||
| M57237 | AZ12601011 | TGF-β Receptor |
| AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth. | ||
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