About 8 results found for searched term "1-EBIO" (0.297 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5318 | Zoligratinib | EGFR/HER2 |
| CH5183284;Debio 1347 | ||
| CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1. | ||
| M6323 | 1-EBIO | Potassium Channel |
| 1-EBIO is a activator of epithelial K Ca channels. | ||
| M10072 | AFN-1252 | Antibiotic |
| API-1252; Debio 1452 | ||
| AFN-1252 (API-1252; Debio-1452) is an enoyl-(acyl-carrier protein) reductase fabl inhibitor. AFN-1252 exhibits typical MIC90 values of ⩽0.015 μg/ml against diverse clinical isolates of S. aureus. | ||
| M39779 | 17α-Thevebioside | Others |
| 17α-Thevebioside is the compound isolated from air-dried leaves of Cerbera manghas and C. odollam. | ||
| M21232 | MeBIO | GSK-3 |
| 6-bromoindirubin-3'-oxime | ||
| MeBIO, an analog of 6-bromoindirubin-3'-oxime, has been suggested to possess the structural basis for a potent and selective inhibitor of glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinases. MeBIO displays minimal activity against CDK1/Cyclin B, GSK-3, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist. | ||
| M28184 | Debio 0617B | STAT |
| Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors. | ||
| M28561 | Afabicin disodium | Antibiotic |
| Debio 1450 disodium; AFN-1720 disodium | ||
| Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. | ||
| M28562 | Afabicin | Antibiotic |
| Debio 1450; AFN-1720 | ||
| Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. | ||
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