Free shipping on all orders over $ 500

Afabicin

Cat. No. M28562

All AbMole products are for research use only, cannot be used for human consumption.

Afabicin Structure
Synonym:

Debio 1450; AFN-1720

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

Chemical Information
Molecular Weight 485.43
Formula C23H24N3O7P
CAS Number 1518800-35-5
Form Solid
Solubility (25°C) Water 3.85 mg/mL (ultrasonic and warming and adjust pH to 10 with NaOH and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] J Nowakowska, et al. J Antimicrob Chemother. Evaluation of the microbiota-sparing properties of the anti-staphylococcal antibiotic afabicin

[2] Virginie Dyon-Tafani, et al. Int J Antimicrob Agents. Antimicrobial activity of the new FabI inhibitor afabicin desphosphono against intraosteoblastic Staphylococcus aureus

[3] Frederick Wittke, et al. Antimicrob Agents Chemother. Afabicin, a First-in-Class Antistaphylococcal Antibiotic, in the Treatment of Acute Bacterial Skin and Skin Structure Infections: Clinical Noninferiority to Vancomycin/Linezolid

[4] Frédéric Peyrusson, et al. Int J Antimicrob Agents. Cellular pharmacokinetics and intracellular activity of the bacterial fatty acid synthesis inhibitor, afabicin desphosphono against different resistance phenotypes of Staphylococcus aureus in models of cultured phagocytic cells

[5] Annick Menetrey, et al. Antimicrob Agents Chemother. Bone and Joint Tissue Penetration of the Staphylococcus-Selective Antibiotic Afabicin in Patients Undergoing Elective Hip Replacement Surgery

Related Antibiotic Products
N-Hydroxypipecolic acid

N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection.
Rosoxacin

Rosoxacin (Acrosoxacin) is an orally active and broad-spectrum antibacterial quinolone antibiotic. Rosoxacin inhibits Gram-negative bacteria, including N. gonorrhoeae (MIC range=0.03-0.125 µg/mL).
2-Nitrosopyridine

2-Nitrosopyridine is a nitroso compound that can be used to synthesize antibiotics. 2-Nitrosopyridine can be used as a Click or Diels-Alder derivatization reagent and an excellent dienophile.
Cethromycin

Cethromycin (ABT-773) is a ketolide antibiotic.
Nacubactam

Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases.

  Catalog
Abmole Inhibitor Catalog




Keywords: Afabicin, Debio 1450; AFN-1720 supplier, Antibiotic, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.