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Zetomipzomib maleate

Cat. No. M21515
Zetomipzomib maleate Structure

KZR-616 maleate

Size Price Availability
5mg USD 1800  USD1800 Out of stock
10mg USD 2850  USD2850 Out of stock
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Quality Control & Documentation
Biological Activity

Zetomipzomib (KZR-616) maleate is a first-in-class inhibitor of immunoproteasome that selectively targets the immunoproteasome subunit LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50:131/179 nM=hLMP7/mLMP7). Potential of Zetomipzomib maleate for use in multiple autoimmune diseases.

Chemical Information
Molecular Weight 702.75
Formula C34H46N4O12
CAS Number 2170983-62-5
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage 2-8℃, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Zetomipzomib maleate, KZR-616 maleate supplier, Proteasome, inhibitors, activators

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