Certificate of Analysis

 

Product Name: Zetomipzomib maleate
Catalog Number: M21515
CAS Number: 2170983-62-5

Physical and Chemical Properties
Formula: C34H46N4O12
Molecular Weight: 702.75
Solubility: DMSO ≥ 200 mg/mL
Storage: 2-8℃, dry, sealed
Chemical Structure: Zetomipzomib maleate Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: Zetomipzomib (KZR-616) maleate is a first-in-class inhibitor of immunoproteasome that selectively targets the immunoproteasome subunit LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50:131/179 nM=hLMP7/mLMP7). Potential of Zetomipzomib maleate for use in multiple autoimmune diseases.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.