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WHI-P97 effectively inhibited the in vitro invasiveness of EGFR-positive human cancer cells in a concentration-dependent manner. WHI-P97 was very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5 microg/kg to 50 mg/kg, and LD(10) was not reached at a 50 mg/kg dose level when administered as a single i. p. or i.v. bolus dose.
| Molecular Weight | 455.1 |
| Formula | C16H13Br2N3O3 |
| CAS Number | 211555-05-4 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Wong WS, et al. Biochim Biophys Acta. Tyrosine kinase inhibitors: a new approach for asthma.
[3] Uckun FM, et al. Curr Cancer Drug Targets. Structure-based design of novel anticancer agents.
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