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VU0529331 

Cat. No. M28117

All AbMole products are for research use only, cannot be used for human consumption.

VU0529331  Structure

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Quality Control & Documentation
Biological Activity

VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel.

Chemical Information
Molecular Weight 384.43
Formula C22H20N6O
CAS Number 1286725-49-2
Form Solid
Solubility (25°C) DMSO 5 mg/mL (Need ultrasonic and warming)
Storage Powder -20°C
References

[1] Meng Cui, et al. J Biol Chem. A novel small-molecule selective activator of homomeric GIRK4 channels

[2] Boris Shalomov, et al. J Physiol. A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5)

[3] Krystian A Kozek, et al. ACS Chem Neurosci. Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels

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  Catalog
Abmole Inhibitor Catalog




Keywords: VU0529331  supplier, Potassium Channel, inhibitors, activators

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