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VitaMin U

Cat. No. M20851
VitaMin U Structure
Synonym:

Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine

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Biological Activity

Vitamin U (Methylmethionine chloride) is a vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract.

Chemical Information
Molecular Weight 199.70
Formula C6H14ClNO2S
CAS Number 3493-12-7
Solubility (25°C) Water 39 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gamze Bayrak, et al. J Biochem Mol Toxicol. The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats

[2] Dileknur Topaloglu, et al. J Biochem Mol Toxicol. Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity

[3] Ertan Celik, et al. Toxicol Mech Methods. Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis

[4] T V Kruchinina, et al. Vopr Pitan. [S-methylmethionin (vitamin U): experimental studies and clinical perspective]

[5] Sehkar Oktay, et al. Naunyn Schmiedebergs Arch Pharmacol. The effect of vitamin U on the lung tissue of pentyleneterazole-induced seizures in rats

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Keywords: VitaMin U, Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine supplier, Vitamin, inhibitors, activators

 
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