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Vitamin B12

Cat. No. M6055
Vitamin B12 Structure
Synonym:

Cobalamin, Cyanocobalamin

Size Price Availability Quantity
500mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.

Chemical Information
Molecular Weight 1355.37
Formula C63H88CoN14O14P
CAS Number 68-19-9
Solubility (25°C) 75 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shipton MJ, et al. Clin Med (Lond). Vitamin B12 deficiency - A 21st century perspective.

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Keywords: Vitamin B12, Cobalamin, Cyanocobalamin supplier, Vitamin, inhibitors, activators


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