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Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities. Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 µM, respectively). It is also active against P. falciparum, including chloroquine-susceptible and -resistant strains (IC50s = 0.85 and 0.63 µM, respectively). It reduces parasitemia in a mouse model of nonlethal P. chabaudi chabaudi infection when administered at a dose of 7.5 mg/kg and increases survival in a mouse model of lethal P. chabaudi chabaudi infection. Violacein permeabilizes the cytoplasmic membrane of bacterial cells but does not affect the cell wall.
| Molecular Weight | 343.34 |
| Formula | C20H13N3O3 |
| CAS Number | 548-54-9 |
| Solubility (25°C) | DMSO |
| Storage | -20°C, protect from light |
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