Free shipping on all orders over $ 500

VH032

Cat. No. M14867
VH032 Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

VH032 is a VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. VH032 is a VHL/HIF-1α interaction inhibitor with a Kd value of 185 nM.

Chemical Information
Molecular Weight 472.6
CAS Number 1448188-62-2
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Julianty Frost, et al. Von Hippel-Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein

[2] Hanqiao Xu, et al. Development of Agonist-Based PROTACs Targeting Liver X Receptor

[3] Wenwei Lin, et al. Development of BODIPY FL VH032 as a High-Affinity and Selective von Hippel-Lindau E3 Ligase Fluorescent Probe and Its Application in a Time-Resolved Fluorescence Resonance Energy-Transfer Assay

[4] Victoria G Klein, et al. Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

[5] Hannah Tovell, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

Related Ligand for E3 Ligase Products
2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2,6-Bis(benzyloxy)pyridine-3-boronic acid

2,6-Bis(benzyloxy)pyridine-3-boronic acid

2,6-Bis(benzyloxy)-3-bromopyridine

2,6-Bis(benzyloxy)-3-bromopyridine

2,6-bis(benzyloxy)pyridin-3-amine

2,6-bis(benzyloxy)pyridin-3-amine

3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione

3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione

  Catalog
Abmole Inhibitor Catalog




Keywords: VH032 supplier, Ligand for E3 Ligase, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.