All AbMole products are for research use only, cannot be used for human consumption.
VBIT-4 is a voltage-dependent anion channel (VDAC1) oligomer inhibitor with a Kd value of 17 μM.In addition, VBIT-4 is an inhibitor of apoptosis and can be used in studies related to neurodegenerative and cardiovascular diseases.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Male 5 × FAD transgenic mice |
| Formulation | dissolved in DMSO (80 mg/ml) and then diluted in drinking water to a final concentration of 0.0625 mg/ml |
| Dosages | 20 mg/kg |
| Administration | given in the drinking water |
| Molecular Weight | 457.87 |
| Formula | C21H23ClF3N3O3 |
| CAS Number | 2086257-77-2 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage | -20°C |
| Related VDAC Products |
|---|
| Tuvatexib
Tuvatexib is a dual VDAC/HK2 small molecule modulator for studies related to squamous cell carcinoma. |
| WEHI-9625
WEHI-9625 is a first-in-class tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX. |
| DIDS sodium salt
DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor. DIDS sodium salt is also an anion transport inhibitor, which inhibits the ClC-Ka chloride channel and the bacterial ClC-ec1Cl-/H+ exchanger with IC50s of 100 μM and ~300 μM, respectively. |
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