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DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor. DIDS sodium salt is also an anion transport inhibitor, which inhibits the ClC-Ka chloride channel and the bacterial ClC-ec1Cl-/H+ exchanger with IC50s of 100 μM and ~300 μM, respectively. DIDS reduced the amplitude of spontaneous transient inward currents (STICs) in a concentration-dependent manner with IC50 value of 2.1 x 10-4 M for STICs. Moreover, DIDS was investigated for its action on contraction of cerebral artery smooth muscle cells. DIDS showed a vasodilator effect on pressure-constricted arteries with IC50 of 69 ± 14 μM.
| Molecular Weight | 498.48 |
| Formula | C16H8N2Na2O6S4 |
| CAS Number | 67483-13-0 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 25 mg/mL |
| Storage | -20°C, dry, sealed |
| Related VDAC Products |
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| VBIT-4
VBIT-4 is a voltage-dependent anion channel (VDAC1) oligomer inhibitor with a Kd value of 17 μM.In addition, VBIT-4 is an inhibitor of apoptosis and can be used in studies related to neurodegenerative and cardiovascular diseases. |
| Tuvatexib
Tuvatexib is a dual VDAC/HK2 small molecule modulator for studies related to squamous cell carcinoma. |
| WEHI-9625
WEHI-9625 is a first-in-class tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX. |
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