URAT1&XO inhibitor 2 is a dual inhibitor of xanthine oxidase and URAT1, with IC50 of 3.3 μM for xanthine oxidase.
| Molecular Weight | 322.15 |
| Formula | C14H12BrNO3 |
| CAS Number | 1239488-96-0 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Nicola Dalbeth et al. Lancet. Gout
[4] Robert T Keenan. Semin Arthritis Rheum. The biology of urate
| Related Xanthine Oxidase Products |
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| TEI-6469
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| Phytic acid dodecasodium hydrate
Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. |
| Ellagic acid-4-O-beta-D-xylopyranoside
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| Protosappanin A dimethyl acetal
Protosappanin A dimethyl acetal is a homoisoflavonoid. |
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