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Topiroxostat (FYX-051) is a novel and potent xanthine oxidoreductase (XOR) inhibitor with IC50 value of 5.3 nM. Topiroxostat (FYX-051) exhibited competitive-type inhibition with a Ki value of 5.7 × 10-9 M of native XO.
In vivo: In this hyperuricemic model, Topiroxostat in the dose range of 0.03 to 1 mg/kg caused a dose-dependent decrease in serum urate levels with an extremely low ED50 of 0.15 mg/kg, evaluated at 1 h after oral administration.
| Molecular Weight | 248.24 |
| Formula | C13H8N6 |
| CAS Number | 577778-58-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Xanthine Oxidase Products |
|---|
| Purpurogallin
Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects. |
| H-Tyr-Phe-OH
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. |
| TEI-6469
TEI-6469 is a xanthine oxidase (XO) inhibitor that may be used in studies related to gout. |
| Phytic acid dodecasodium hydrate
Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. |
| Ellagic acid-4-O-beta-D-xylopyranoside
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an 50 of 2.1 μg/mL. |
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