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TPEN

Cat. No. M10165
TPEN Structure
Synonym:

TPEDA

Size Price Availability Quantity
50mg USD 60  USD60 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN attenuates Fura-2 fluorescence changes induced by cadmium, mercury, and methylmercury. In cells stimulated with cadmium chloride (10/30 μM), the addition of TPEN at 3 h after exposure significantly decreases the elevated Fura-2 fluorescence ratio to the basal levels within 10 min (119.6±2.4% or 109±1.5% decrease in ΔRatio (F340/F380)).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 424.54
Formula C26H28N6
CAS Number 16858-02-9
Purity >99%
Solubility DMSO ≥ 10 mg/mL
Storage at -20°C
References

[1] Omar Nasser Rahal, et al. Cancer Biol Ther. Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells

[2] Masato Ohkubo, et al. J Vet Med Sci. Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TPEN, TPEDA supplier, Autophagy, inhibitors

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