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Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab, a immunosuppressive drug, has the potential for active systemic lupus erythematosus (SLE) research.
| CAS Number | 252662-47-8 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[4] James E Crowe Jr, et al. Am J Transplant. CD154 regulates primate humoral immunity to influenza
[5] Francis J Dumont. Curr Opin Investig Drugs. IDEC-131. IDEC/Eisai
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