Tigatuzumab

Cat. No. M25291

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody

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Quality Control & Documentation

Purity:
COA
MSDS

Product Information

Biological Activity

Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer.

Chemical Information

CAS Number	918127-53-4
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Jun Yamamoto, et al. Cancer Lett. Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model

[2] Ann-Lii Cheng, et al. J Hepatol. Safety and efficacy of tigatuzumab plus sorafenib as first-line therapy in subjects with advanced hepatocellular carcinoma: A phase 2 randomized study

[3] Andres Forero-Torres, et al. Cancer Med. Phase 2, multicenter, open-label study of tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5, in combination with gemcitabine in chemotherapy-naive patients with unresectable or metastatic pancreatic cancer

[4] Kuen-Feng Chen, et al. Biochem Pharmacol. Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3

[5] Andres Forero-Torres, et al. Cancer Biother Radiopharm. Phase I trial of weekly tigatuzumab, an agonistic humanized monoclonal antibody targeting death receptor 5 (DR5)

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Tigatuzumab

CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody

Quality Control & Documentation

Biological Activity

Chemical Information

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