Thyroglobulin is an excellent source of N-linked glycans of various structures, including sialylated core fucose and oligomannose oligosaccharides. Native thyroglobulin, consisting of two polypeptide homodimers of 330 kDa each, purified from bovine thyroid.
| CAS Number | 9010-34-8 |
| Solubility (25°C) | Soluble in water Soluble in aqueous buffer |
| Storage | -20°C, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Francesca Coscia, et al. Nature. The structure of human thyroglobulin
[4] A D LITONJUA. Nature. Thyroglobulin
[5] V Deshpande. Comp Biochem Physiol B. Buffalo thyroglobulin
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