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Thymidine 3',5'-disphosphate

Cat. No. M29840
Thymidine 3',5'-disphosphate Structure
Synonym:

Deoxythymidine 3′,5′-diphosphate; pdTp

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Biological Activity

Thymidine 3',5'-disphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) is a selective small molecule inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the miRNA regulatory complex RISC subunit) and inhibits SND1 activity. Thymidine 3',5'-disphosphate exhibits anti-tumor efficacy in vivo.

Chemical Information
Molecular Weight 402.19
Formula C10H16N2O11P2
CAS Number 2863-04-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Pogban Toure, et al. Org Lett. Thymidine 3',5'-diphosphoric acid derived cations and radicals: ab initio study

[2] W J Chuang, et al. Proteins. Mutational tests of the NMR-docked structure of the staphylococcal nuclease-metal-3',5'-pdTp complex

[3] D J Weber, et al. Proteins. NMR docking of the competitive inhibitor thymidine 3',5'-diphosphate into the X-ray structure of staphylococcal nuclease

[4] K Iwahashi, et al. J Biochem. Further evidence for the existence of the p0 site in the active site of ribonuclease. The binding of thymidine 3',5'-diphosphate to ribonuclease

[5] J F Wang, et al. Biochemistry. Two-dimensional NMR studies of staphylococcal nuclease: evidence for conformational heterogeneity from hydrogen-1, carbon-13, and nitrogen-15 spin system assignments of the aromatic amino acids in the nuclease H124L-thymidine 3',5'-bisphosphate-Ca2+ terna䲧瘀Ỵ瘁㧀

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Keywords: Thymidine 3',5'-disphosphate, Deoxythymidine 3′,5′-diphosphate; pdTp supplier, Apoptosis, inhibitors, activators

 
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